Detalhe da pesquisa
1.
Pharmacokinetics and safety of EVER206, a novel polymyxin antimicrobial, in healthy Chinese subjects.
Antimicrob Agents Chemother
; : e0156323, 2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647294
2.
First-in-human study to evaluate the safety, tolerability, and population pharmacokinetic/pharmacodynamic target attainment analysis of FL058 alone and in combination with meropenem in healthy subjects.
Antimicrob Agents Chemother
; 68(1): e0133023, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38054726
3.
Single-Ascending-Dose, Food-Effect, and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Pangenotypic Anti-Hepatitis C Virus Drug Holybuvir in Healthy Chinese Subjects.
Antimicrob Agents Chemother
; 67(3): e0129522, 2023 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36809048
4.
A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects.
Antimicrob Agents Chemother
; 67(11): e0079623, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37902402
5.
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections.
Antimicrob Agents Chemother
; 66(6): e0243021, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35575579
6.
Pharmacokinetic evaluation and relative bioavailability pilot study of fidaxomicin in healthy Chinese subjects: An open, randomized, single-dose, cross-over study.
Int J Clin Pharmacol Ther
; 60(10): 448-458, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35979900
7.
Pharmacokinetics and Disposition of Contezolid in Humans: Resolution of a Disproportionate Human Metabolite for Clinical Development.
Antimicrob Agents Chemother
; 65(11): e0040921, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34398672
8.
Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.
Antimicrob Agents Chemother
; 65(8): e0035021, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972256
9.
Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human.
Pharm Res
; 38(1): 79-87, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496870
10.
Clinical experience with isavuconazole in healthy volunteers and patients with invasive aspergillosis in China, and the results from an exposure-response analysis.
Mycoses
; 64(4): 445-456, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355949
11.
Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229495
12.
Pharmacokinetics and pharmacodynamics of multiple-dose intravenous nemonoxacin in healthy Chinese volunteers.
Antimicrob Agents Chemother
; 59(3): 1446-54, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25534726
13.
Determination of a novel nonfluorinated quinolone, nemonoxacin, in human feces and its glucuronide conjugate in human urine and feces by high-performance liquid chromatography-triple quadrupole mass spectrometry.
Biomed Chromatogr
; 29(5): 739-48, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25322721
14.
Safety, tolerability, and pharmacokinetics of intravenous nemonoxacin in healthy chinese volunteers.
Antimicrob Agents Chemother
; 58(10): 6116-21, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25092690
15.
Determination of pinocembrin in human plasma by solid-phase extraction and LC/MS/MS: application to pharmacokinetic studies.
Biomed Chromatogr
; 28(12): 1601-6, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733513
16.
Pharmacokinetic and safety profiles of mesalazine enema in healthy Chinese subjects: A single- and multiple-dose study.
PLoS One
; 19(2): e0296940, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306390
17.
Population pharmacokinetics of levornidazole in healthy subjects and patients, and sequential dosing regimen proposal using pharmacokinetic/pharmacodynamic analysis.
Int J Antimicrob Agents
; 61(4): 106754, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36773938
18.
Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects.
Antibiotics (Basel)
; 12(9)2023 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37760689
19.
Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of Mirogabalin in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Study.
Adv Ther
; 40(4): 1628-1643, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36790683
20.
Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia.
Front Pharmacol
; 14: 912962, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923351